COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the five sessions with a 2 weeks wash out period in-between. Paracetamol alone was used as control. This was compared with concomitant administration with Cimetidine and then delayed (l hour later) administration of paracetamol after Cimetidine. Diazepam was used in phase IV and V under the same protocol of concomitant administration with paracetamol and delayed administration of paracetamol l hour of diazepam. Ultraviolet spectrophotometer was used to determine the saliva concentration of paracetamol. Pharmacokinetic parameters (Kab, t1/2el, t1/2(ab), Kel, Kab, lag time were determined by plotting paracetamol concentrations against time on a logarithmic scale while other parameters were calculated. There was no significant effect (p > 0.05) on the parameters on concomiittant administration for both drugs (cimetidine and diazepam) when compared to the control. However, on delayed administration of paracetamol 1 hour after administration of diazepam, Tmax and lag time were greatly reduced 31.11 % and 50 % repectively P < 0.05. T1/2(ab) and Kel were significantly increased 48.42 % and 54.57 % P < 0.05 respectively. The volume of distribution (Vd) and clearance (Cl) were not significantly affected P > 0.05. Delayed administration of paracetamol 1 hour after cimetidine affected all the parameters Cmax and Kab were significantly reduced P < 0.05 by 30.02 % and vii 45.06 % respectively. While Tmax, t1/2(ab) and lag time were significant increased (p < 0.05) by 47.97 %, 42.32 % and 60.13 % respectively. Clearance (Cl) and Kel were reduced significantly (P < 0.05) by 20.75 % and 42,76 % respectively. T1/2(el) and AUC0 - ∞ were increased by 39.20 % and 29.08 % respectively. The above findings show that concomitant administration of paracetamol + diazepam and of paracetamol + cimetidine does not cause any effect on the kinetics of paracetamol. On the other hand, delayed administrations of paracetamol one hour after cimetidine show decrease in absorption and delayed elimination probably due to delay in gastric emptying and inhibition of metabolism respectively. Administration of paracetamol one hour after diazepam ingestion shows increase in absorption and change in other pharmacokinetic parameters due to enhanced gastric emptying and amplitude of contraction.
Related Project Materials
THE INFLUENCE OF LAISSEZ-FAIRE LEADERSHIP ON EMPLOYEE PERFORMANCE
THE INFLUENCE OF LAISSEZ-FAIRE LEADERSHIP ON EMPLOYEE PERFORMANCE
This study examines...
PHARMACOGNOSTIC AND PRO-FERTILITY EVALUATIONS OF DRACAENA ARBOREA (WILLD) LINN. (DRACAENACEAE)
ABSTRACT
The plant Dracaena arborea (Willd) Linn is a member of the Dracaenaceae family. It grows abundantly in western Nigeria where its...
ROLE OF WOMEN IN TACKLING CORRUPTION IN NIGERIA
Background to the Study
The changing impact of corruption in Nigeria is felt by every man in the countr...
THE INFLUENCE OF ALCOHOL ON HEALTH BEHAVIOR OF YOUTH IN EGOR LOCAL GOVERNMENT
Abstract
Alcohol consumption among different ethnic groups in Nigeria has a long history, especially among those groups...
THE ROLE OF COST MANAGEMENT IN PROJECT SUCCESS
Abstract: This research explores the role of cost management in project success, aiming to: 1) identify best...
Correlational Study of Attitude towards Physical Exercise, Active Ageing and Quality of Life: Implications for Geriatric Counseling
Abstract
This study investigated the frequency of physical exercise of young and middle aged Nigerian adults, their perceived relevance o...
IMPACT OF EXPERIENTIAL LEARNING ON ADULT LEARNERS
Abstract: This research examines the impact of experiential learning on adult learners. The study aimed to explore how hands-on, practical lea...
ACCOUNTING FOR INTANGIBLE ASSETS IN PUBLIC ACCOUNTING ENGAGEMENTS
ACCOUNTING FOR INTANGIBLE ASSETS IN PUBLIC ACCOUNTING ENGAGEMENTS
This research examines the accounting for intangible assets in public a...
THE INFLUENCE OF GEOPOLITICAL EVENTS ON INVESTMENT DECISIONS
ABSTRACT
THE INFLUENCE OF GEOPOLITICAL EVENTS ON INVESTMENT DECISIONS
This study examines the influence of geopolitical events...
BLOOD RELATIONSHIP AS A BASIS OF INHERITANCE UNDER ISLAMIC LAW: A CASE STUDY OF THE INNER AND OUTER CIRCLES OF FAMILY
ABSTRACT
The life on earth depends largely on inheritance from generation to generation for its continuous existence. Without inheritance...
