0704-883-0675     |      dataprojectng@gmail.com

COMPARISON OF THE EFFECTS OF CIMETIDINE AND DIAZEPAM ON THE PHARMACOKINETICS OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the five sessions with a 2 weeks wash out period in-between. Paracetamol alone was used as control. This was compared with concomitant administration with Cimetidine and then delayed (l hour later) administration of paracetamol after Cimetidine. Diazepam was used in phase IV and V under the same protocol of concomitant administration with paracetamol and delayed administration of paracetamol l hour of diazepam. Ultraviolet spectrophotometer was used to determine the saliva concentration of paracetamol. Pharmacokinetic parameters (Kab, t1/2el, t1/2(ab), Kel, Kab, lag time were determined by plotting paracetamol concentrations against time on a logarithmic scale while other parameters were calculated. There was no significant effect (p > 0.05) on the parameters on concomiittant administration for both drugs (cimetidine and diazepam) when compared to the control. However, on delayed administration of paracetamol 1 hour after administration of diazepam, Tmax and lag time were greatly reduced 31.11 % and 50 % repectively P < 0.05. T1/2(ab) and Kel were significantly increased 48.42 % and 54.57 % P < 0.05 respectively. The volume of distribution (Vd) and clearance (Cl) were not significantly affected P > 0.05. Delayed administration of paracetamol 1 hour after cimetidine affected all the parameters Cmax and Kab were significantly reduced P < 0.05 by 30.02 % and vii 45.06 % respectively. While Tmax, t1/2(ab) and lag time were significant increased (p < 0.05) by 47.97 %, 42.32 % and 60.13 % respectively. Clearance (Cl) and Kel were reduced significantly (P < 0.05) by 20.75 % and 42,76 % respectively. T1/2(el) and AUC0 - ∞ were increased by 39.20 % and 29.08 % respectively. The above findings show that concomitant administration of paracetamol + diazepam and of paracetamol + cimetidine does not cause any effect on the kinetics of paracetamol. On the other hand, delayed administrations of paracetamol one hour after cimetidine show decrease in absorption and delayed elimination probably due to delay in gastric emptying and inhibition of metabolism respectively. Administration of paracetamol one hour after diazepam ingestion shows increase in absorption and change in other pharmacokinetic parameters due to enhanced gastric emptying and amplitude of contraction.





Related Project Materials

THE EFFECTS OF MILITANCY ON DEVELOPMENT OF THE NIGERIA STATES

ABSTRACT

For so many years, the Niger Delta Region has been oppressed by the Military and Civilian Government. This rese...

Read more
CONFLICT OF PRINCIPALS AND STAFF RELATIONSHIP AS IT AFFECTS SECONDARY SCHOOL ADMINISTRATION IN IHIALA PRIMARY SCHOOL ZONE IN IHIALA LOCAL GOVERNMENT AREA OF ANAMBRA STATE

ABSTRACT

This study was carried out to evaluate Conflict of principals and staff relationship as it affects secondary school administrati...

Read more
INFLUENCE OF LEADERSHIP STYLE ON EMPLOYEES’ PERFORMANCE IN GOVERNMENT ESTABLISHMENTS

ABSTRACT

The study examined the influence of leadership style on employees’ performance in govern...

Read more
INNOVATIONS IN ASSESSING CREATIVITY AND INNOVATION IN TECHNICAL EDUCATION

Abstract: Innovations in assessing creativity and innovation in technical education are ess...

Read more
THE ROLE OF ACCOUNTING FOR INTERNATIONAL JOINT VENTURES AND ALLIANCES

 THE ROLE OF ACCOUNTING FOR INTERNATIONAL JOINT VENTURES AND ALLIANCES

ABSTRACT

This research aims to examine (1) the role...

Read more
EFFECTS OF POSITIVE REINFORCEMENT AND SOCIAL SKILLS TRAINING COUNSELLING TECHNIQUES ON SULLENNESS AMONG SENIOR SECONDARY SCHOOL STUDENTS

ABSTRACT

This study investigated the effects of positive reinforcementand social skills training counselling techniques on sullenness amo...

Read more
EQUITY AND INCLUSION IN VOCATIONAL EDUCATION ACCESS

ABSTRACT: Addressing Equity and Inclusion in Vocational Education Access explores strategies to promote equitable access and inclusion in vocationa...

Read more
THE CONSEQUENCES OF DIVORCE IN BENIN KINGDOM

ABSTRACT

Marriage is a sacred institution that must be well prepared for. Failure to plan before entering the union is...

Read more
ANALYSIS EFFECT OF MORTALITY DEATH RATE ON WOMEN AGE GROUP

ABSTRACT

This study was carried out to examine the effect of mortality death rates on women age  g...

Read more
IMPACT OF TUNGAN-KAWO IRRIGATION SCHEME ON RICE PRODUCTION IN WUSHISHI LOCAL GOVERNMENT AREA, NIGER STATE, NIGERIA

ABSTRACT

The study seeks to examine the impact of Tungan-kawo irrigation scheme on rice production in Wushishi Local Government Area, Nig...

Read more
Share this page with your friends




whatsapp